Their results also suggested that both β‐cellproliferation, as well as insulin secretion induced byGLP‐1receptor (GLP‐1R) activation, are regulated by two distinct signaling pathways 3. Then, what is the molecular mechanism that mediates the age‐dependent human β‐cellproliferation induced by GLP‐1R agonists?
Glucagon-like peptide-1 (GLP-1)andglucagon-like peptide-2 (GLP-2) are related intestinal L-cell derived secretory products.GLP-1has been extensively studied in terms of its influence on metabolism, but less attention has been devoted to GLP-2 in this regard. The current study compares the effects of these proglucagon-derived peptides on pancreaticbeta-cellfunction, as well as on glucose ...
The corresponding ligand,GLP-1, is secreted from enteroendocrine Lcellsin response to nutrient stimulation, and its activation ofGLP-1Rs result in insulin secretion and inhibited glucagon secretion from receptors expressed atbetacellsandalphacells, respectively, reduced gastric emptyingratefromGLP-1Rs in the ventricle and ...
GLP-1andits analogs enhance insulin secretion, but the specific intracellular mechanisms in β-cellsremain unclear. Key intracellular mediators including calcium, glutamate, γ-aminobutyric acid, serotonin, and urocortin-3 are modulated byGLP-1signaling with variable and sometimes contradictory effects.GLP-1may affect mitochondrial dynamics and redox balance in β-cells, both critical ...
Introduction: Diabetes mellitus (DM) is a global health challenge characterized by progressivebetacelldysfunction. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as promising therapies, enhancing insulin secretion while potentially preservingbetacellmass by inhibiting apoptosis. However, concerns persist regarding long-termbetacelladaptation and functional ...
